The classical examples of human diseases are neuromyelitis optica spectrum disorders with antibodies against the astrocytic water channel aquaporin 4 (Lennon, Kryzer, Pittock, Verkman, & Hinson, 2005) and the inflammatory demyelinating disease associated with specific demyelinating autoantibodies against myelin oligodendrocyte glycoprotein (Hennes, Baumann, Lechner, & Rostasy, 2018). The gene discussed is MOG; the disease is neuromyelitis optica.