TNPO2 and malignant pleural mesothelioma: In Hela cells, knockdown of TNPO2 can lead to cytoplasmic accumulation of HuR protein, aggravating apoptosis.13 Recent studies have shown that TNPO2 is highly expressed in malignant pleural mesothelioma (MPM) tissues as well as cells, and this might formally represent a novel cancer‐specific gene.