CD274 and lung cancer: Different lung cancer subtypes have a different biologic background and tissue characteristics.24 Subsequent genomic analysis indicated that TMIT was associated with mutation and neoantigen numbers in LAC but not in SCC.17 Based on the IHC analysis, some study reported that PD‐L1 expression was related to a longer25 or a shorter26, 27 survival of NSCLC patients, or was even not correlated with their survival.28 In this respect, tumor cell PD‐L1 IOD value was associated with prolonged survival in SCC, but immune cell expression was correlated with poor prognosis in LAC.