IRS‐1 may mediate the inhibition of Ca2+ mobilization through insulin.38 In T2DM patients, SNPs of rs956115 and rs13431554 in IRS‐1 have hyperreactive platelets and suffer from a risk of ischemic events.39 IRS‐independent pathways contribute to platelet hyperreactivity due to impaired responses to nitric oxide (NO) and prostacyclin, which are related to CR.40 In our study, GCK, influenced by DNA methylation, could affect platelet activity in response to clopidogrel, which was also involved in insulin deficiency. This evidence concerns the gene INS and type 2 diabetes mellitus.