A recent investigation reported that aberrant DNA methylation might participate in the occurrence and development of atherosclerotic plaques26 and coronary heart disease.27 Furthermore, some studies have demonstrated that changes in ABCB1,28 ABCC3,29 P2Y12,17 and PON118 promoter methylation levels were associated with a decline in clopidogrel antiplatelet effects. This evidence concerns the gene ABCC3 and coronary artery disorder.