Phagocytosis and antigen uptake is downregulated,73, 74, 75 antigen presentation is reduced,57, 65, 73, 75, 76 apoptosis increases,73, 75 there is increased induction of IL‐10‐producing regulatory T cells (Treg),77 and they upregulate inhibitory ligand LAG‐3, a negative regulator of T cell proliferation.57 Yet they also express co‐stimulatory markers, particularly during peak parasitemia and post‐treatment,75, 76, 78, 79 suggesting that APCs are activated but may be polarized to initiate regulatory responses. Here, LAG3 is linked to parasitic infectious disease.