In CHMI, subjects with significantly higher baseline transcript levels of Treg‐associated markers CD27, IL2Ra, CD4, ICOS, IRF4, and Runx1140, 141, 142, 143 are worse at controlling parasitemia,84 and Treg induction in CHMI results in impaired central memory development.69 TGF‐β, which is required to drive Treg differentiation,144 is one of the principal cytokine phenotypes observed in CHMI.60 Here, TGFB1 is linked to parasitic infectious disease.