162, 163 This recent new concept in immunology164, 165, 166 describes how particular microbial antigens, including bacille Calmette‐Guerin (BCG) vaccination167, 168, 169 and lipopolysaccharide,170 but also Plasmodium spp.,171, 172, 173 can induce epigenetic modifications in innate cells which alter responsiveness to heterologous stimuli. Indeed, subjects receiving BCG five weeks prior to malaria challenge develop higher levels of circulating IFN‐γ in response to CHMI,174 leading to higher NK cell cytotoxicity that correlates with delayed time to parasitemia. Here, IFNG is linked to malaria.