Studies in several murine malaria models show that inhibitory ligands are frequently associated with increased pathology and higher parasitemia.127 PD‐1 signaling reduces CD8+ T responsiveness and increases apoptosis.127 Combined PD‐1 and LAG‐3 blockade may decrease morbidity by reducing suppression of Tfh.128. The gene discussed is PDCD1; the disease is malaria.