Especially in HER2, the positive ratio of grade 3 specimens was markedly lower than that of grade 2 (primary: 27.3% for grade 2 and 8.7% for grade 3; LN: 28.6% for grade 2; and 7.4% for grade 3), and the similar findings are already reported: the intestinal type (well-differentiated) gastric cancer exhibited high HER2-positive ratio compared with diffuse (poorly differentiated) type gastric cancer [17–19]. The gene discussed is ERBB2; the disease is gastric cancer.