TARDBP and amyotrophic lateral sclerosis: The majority of ALS-associated TDP-43 mutations have so far been found to occur within the low complexity ‘prion-like’ C-terminal domain (amino acids 274 to 414, Fig. 1E), which is involved in interactions with other proteins (Buratti et al., 2005; D'Ambrogio et al., 2009; March et al., 2016).