Finally, in primary human glioma samples, IHC scores for PMEPA1 negatively correlated with scores for LATS1 (P < 0.01) and positively correlated with scores for CYR61 (P < 0.05), indicating a possible relationship between the proteins, while no significant correlation was found between PMEPA1 and p-YAP (Ser127) (Fig. 7g, h). This evidence concerns the gene CCN1 and central nervous system cancer.