According to TCGA database, MYH9, DHX9, DDB1, and HMGB1 do not show distinct expression levels between nonneoplastic and GBM samples (Data not shown here), while VDAC1 had been reported to play a role in GBM cell metabolism and MTA2 expression level was related to glioma cells proliferation and invasion [30, 31]. This evidence concerns the gene HMGB1 and central nervous system cancer.