As shown in Fig. 3, increase in ALR2 activity due to hyperglycemia resulted in an increase in the level of sorbitol (1801.21 ± 199.25 nmoles/g lens, p < 0.05) in STZ-induced rats as compared with the controls (650.32 ± 136.21 nmoles/ g lens). This evidence concerns the gene AKR1B1 and Hyperglycemia.