IRF5 and early-onset autosomal dominant Alzheimer disease: These include a known homozygous SNP (rs2004640) in IRF5 gene that has been shown to be associated with Rheumatoid Arthritis, a heterozygous deletion (rs1799759) in the A2M gene that is a risk factor for the susceptibility to Alzheimer’s disease, and a heterozygous SNP (rs10774671) known to result in the loss of function of the OAS1 gene, a high impact risk factor for susceptibility to Type 1 Diabetes.