INS and Insulin resistance: Consistent with the increase in fasting insulin levels, a trend towards worsened insulin resistance as measured via an ITT was observed in the CD40fl/flCD11ccre mice fed HFD compared to WT mice (area under the curve of 34.0 (mean) ± 7.9 (SD) in HFD WT mice vs 44.3 ± 15.2 in HFD CD40fl/flCD11ccre mice, unpaired t-test, p = 0.1113, Fig. 2E,F).