Although the mechanisms of synergistic pathogenesis in viral-bacterial coinfections have remained elusive, on the basis of published studies and our findings here, it is plausible that HCMV infection may directly contribute to increased susceptibility to intestinal invasive bacteria by selectively targeting TLR3 and TLR4 and, furthermore, may be a considerable risk factor for developing the severity of secondary bacterial infections or IBD. This evidence concerns the gene TLR4 and cytomegalovirus infection.