We then extracted tissue and cancer type-specific peak sets from ATAC-seq-based chromatin accessibility data sets12,13 for hematopoietic lineages, prostate adenocarcinoma (PRAD), breast cancer (BRCA), and colon adenocarcinoma (COAD) and calculated individual TF accessibilities (see the Methods section). The gene discussed is TF; the disease is colon adenocarcinoma.