SPI1 and acute leukemia: Furthermore and as predicted by our evaluation of the ATAC-seq data (Supplementary Data 2), the accessibilities for hematopoietic-related TFs, such as LYL1, TAL1 (SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia (T-ALL) 1))29, EVI1, TBX21 (T-bet30), and PU.1 were reduced in all tumor samples (Fig. 2b, c).