We observed already statistically significant different accessibilities between healthy controls and COAD samples for TFs HNF4A and DLX2 (Fig. 4a) and the other TFs, GRHL2, EVX2, LYL1, and PU.1 showed statistically significant differences at a 1% tumor level (Fig. 4a). The gene discussed is GRHL2; the disease is neoplasm.