In the colon cfDNA pool, TFs EVX2, DLX2, HNF1A, HNF4A, and HNF4G and TFs AR and HOXB13 in the prostate cancer cfDNA pool had increased accessibilities (Fig. 3e), whereas FOXA1 exceeded the >5 z-score threshold in both the prostate and breast pool. The gene discussed is HNF4A; the disease is Familial prostate cancer.