Interestingly, APP contains eight putative phosphorylation sites in the cytoplasmic domain, of which seven (Tyr-653, Ser-655, Thr-668, Ser-675, Tyr-682, Thr-686, and Tyr-687 (APP695 numbering)) were recently shown to be phosphorylated in the brains of AD patients (15). Here, APP is linked to Alzheimer disease.