MLH1 (mAb# M1), MSH2 (mAb# G219-1129), and PMS2 (mAb# A16-4) proteins were detected in tumor cell nuclei, whereas MSH6 (mAb# SP93) stained negative in all tumor cell nuclei, suggesting the two nonsense MSH6 variants are in the trans phase in the tumor cells. The gene discussed is MLH1; the disease is neoplasm.