Four loci particular SNPs located in 7p12.2 (IKZF1), 9p12 (CDKN2A/CDKN2B), 10q21.2 (ARID5B) and 14q11.2 (CEBPE) are reported by Sherborne which are associated with ALL risk: RR (1.5–1.6) and more specifically with the B-cell precursor (BCP) ALL [14, 15]. This evidence concerns the gene CDKN2B and acute lymphoblastic leukemia.