According to one report, among 14,599 breast cancer patients with BM, the ER positive rate was 37% (41% negative and the others unknown), the PgR positive rate was 36% (34% negative), the HER-2 positive rate was 35% (41% negative), and the triple negative rate was 27% (18% triple positive) [2]. The gene discussed is ESR1; the disease is breast carcinoma.