SNCA and Parkinson disease: Parkinson’s disease (PD), Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA) are the three main types of synucleinopathies, all of which are characterized by inclusions mainly consisting of intracellular aggregated α-synuclein (α-syn); a 140-amino acid protein with hypothesized unfolded native appearance [1, 2].