ACY1 and occult macular dystrophy: However, plasma levels of GHR, ACY1, and OMD predicted subsequent rates of cognitive change on the DRS in mixed-effects linear models adjusting for age, sex, disease duration, and baseline DRS score, with time-by-protein interaction coefficients of 0.0905 (GHR, FDR-corrected p = 8.72 × 10−6), 0.0478 (ACY1, FDR-corrected p = 2.574 × 10−2), and −0.0457 (OMD, FDR-corrected p = 2.574 × 10−2), respectively.