We compared values of ACY1, OMD, GHR, and BSP in people with PD treated with dopaminergic medication versus those never treated with dopaminergic medications, and we found no significant differences (Wilcoxon test nominal p-value > 0.05 for all four proteins comparing PD treated versus not treated with dopaminergic medication, Fig 3). This evidence concerns the gene ACY1 and Parkinson disease.