GHR and dementia: Using the same Cox proportional hazards models (i.e., adjusted for age, sex, and disease duration) as in the Discovery Cohort, we found that individuals with baseline levels of GHR in the lowest tertile were more likely to progress to MoCA scores in the MCI or dementia range (HR 3.6 [95% CI 1.20–11.1, p = 0.02]) in the Replication Cohort as well (Fig 4G and 4H).