GHR and dementia: Moreover, individuals with baseline levels of GHR and ACY1 in the lowest tertile were significantly more likely to clinically progress to MCI or dementia in Cox proportional hazards analyses adjusting for age, sex, and disease duration (hazard ratio [HR] 2.27 [95% CI 1.04–5.0, p = 0.04] for GHR [Fig 4E and 4F], and HR 3.0 [95% CI 1.24–7.0, p = 0.014] for ACY1 [S3 Fig]).