The role of CSCs in HCC is well documented.32, 33, 34, 35, 36 The CSCs/tumour‐initiating cells can be responsible for cancer initiation, metastasis and resistance to therapy.37, 38, 39 Targeting of EpCAM+, or CD133+ CSCs have been shown to eradicate HCC.34, 35, 40, 41 The role of SATB2 in HCC is not well understood. This evidence concerns the gene SATB2 and cancer.