These structures exhibited a loss in the expression of α‐fetoprotein (tumour marker), and an increase in the expression of cytokeratin 8 (liver cell markers) and cytokeratin 19 (live stem cell marker).45 Oncogene inactivation caused cancer cells to differentiate into normal cellular lineages and tissue structures while retaining their latent potential to become cancerous and thereby showing a dormant stage of tumour.45 Our data suggest that deletion of SATB2 in HCC and CSCs can abolish stemness properties. Here, SATB2 is linked to hepatocellular carcinoma.