Similarly, in the breast, pancreatic and colorectal cancer models we have demonstrated that SATB2 can positively regulate EMT characteristics by modulating the expressions of cadherins, vimentin and EMT‐related transcription factors.14, 15, 16 Overall, our studies suggest that SATB2 can promote EMT and metastasis in HCC. Here, SATB2 is linked to hepatocellular carcinoma.