SATB2 and colorectal cancer: We have recently demonstrated the roles of SATB2 in malignant transformation and maintaining CSCs characteristics by regulating CSC markers and stem cell transcription factors in pancreatic, breast and colorectal cancers.14, 15, 16 Since SATB2 is a transcription factor and modulates stemness, we examined whether inhibition of SATB2 in CSCs by Crisp/Cas9 technique regulates cell viability, expression of stem cell markers and pluripotency maintaining factors.