The acute-phase protein PTX3 has been extensively described as a biomarker in major inflammatory disorders such as stroke, cancer or cardiovascular disease (Bonacina et al., 2013; Ryu et al., 2012; Shindo et al., 2014), and several studies indicate that PTX3 regulates neutrophil transmigration during peripheral inflammation via interaction with P-selectin (a key cell surface adhesion molecule critical for neutrophil recruitment) (Deban et al., 2010; Salio et al., 2008). Here, PTX3 is linked to Stroke.