PTX3 and stroke disorder: Our previous studies in stroke have demonstrated that PTX3 expressed in the brain after experimental cerebral ischemia (induced by occlusion of the middle cerebral artery (MCAo)) plays a critical role in the restoration of blood flow (Rajkovic et al., 2018) and integrity of the BBB (Rodriguez-Grande et al., 2014), and is a key regulator of long-term angiogenesis, neurogenesis and neuroprotection (Rajkovic et al., 2018).