ANGPTL4 and breast cancer: As for breast cancer BM, a previous study has revealed that ANGPTL4 is one of 17 genes within the breast cancer brain metastasis gene set (BrMS) whose expression was correlated with brain relapse in clinically annotated breast tumors and resembled the expression profile of brain-metastatic-derived cells from a mouse model.43 In this study, we found that knockdown of ANGPTL4 in MDA-MB-231 cells significantly reduced the ability of these tumor cells to seed and grow in the brain at 21 days post injection.