For example, adipocyte-derived ANGPTL4 drives disease progression under obese conditions, thus demonstrating that ANGPTL4 produced from other cell types may still promote tumor progression.44 However, this finding is a direct evidence for the tumor-promoting role of ANGPTL4 in breast cancer BM, which provides groundwork to warrant further investigation into targeting ANGPTL4 as a treatment for breast cancer BM. This evidence concerns the gene ANGPTL4 and breast carcinoma.