Radiotherapy may also upregulate MHC class I and FAS adhesion molecules, which may counteract adaptive loss of MHC or beta 2 microglobulin.38 Conversely, radiotherapy can cause immunosuppressive effects, including upregulation of the PD1/PDL1 axis, upregulation of suppressive macrophage receptors including Mertk,39 expansion of Tregs, and possibly apoptosis of tumor infiltrating lymphocytes (TILs). This evidence concerns the gene CD274 and neoplasm.