A male diagnosed with ADHD (206773), who carried a duplication of chromosome X (Klinefelter syndrome), also had ASD, learning disability, language delay, general anxiety disorder, and enuresis, all known feature of Klinefelter syndrome.29 Male case 181220 with ADHD, with 15q11.2 duplication (BP1-BP2), also had ASD. The gene discussed is IGFBP2; the disease is attention deficit-hyperactivity disorder.