SMARCA2 and renal cell carcinoma: In conclusion, the present results indicate that the hypermethylation of BRM promoters plays oncogenic roles by the transcription inhibition of BRM in RCC, and the tumor suppressor gene BRM inhibits RCC cell vitality in vitro and in vivo. Besides, we confirmed that BRM may inhibit the proliferation of human clear cell RCC in vitro by inducing G2/M phase arrest and cell apoptosis.