These results presented in our experimental works indicated that the bidirectional activation of NF-κB and FoxM1 not only may be a key biological marker for promotion of lung cancer stemness, but also may be a molecular target for the inhibitory effects of BrMC on lung cancer stemness of NSCLC H460 cell line induced by pro-inflammatory cytokines. The gene discussed is FOXM1; the disease is lung carcinoma.