And the interaction of ITGB4 promoter with some transcription factors in other disease is also reported, such as KLF4 in glioma 21, RUNX1 in myeloid leukemia 22, ZEB1 in prostate cancer 23, TP73 in lung cancer 24, GLI1 in ovarian cancer 25, and JUN in pancreatic cancer 26. The gene discussed is KLF4; the disease is central nervous system cancer.