Our previous studies have shown that, AIB1 overexpression seems to indicate an aggressive phenotype of non-muscle-invasive bladder cancer with high risk of disease progression after initial treatment, and our further functional and mechanistic study revealed that AIB1 promotes bladder cancer cell proliferation and tumor growth by activating the AKT pathway and acting as coactivator of E2F129. Here, NCOA3 is linked to urinary bladder cancer.