We found that members of the HLA complex, HLA-A, HLA-C, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB4, HLA-DRB6 and HLA-E, showed significant diagnostic values for HCC. This evidence concerns the gene HLA-DOA and hepatocellular carcinoma.