Dianwu Liu et al. suggested that thirty four variants of eight HLA genes, including HLA-B, HLA-C, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DQB2, HLA-DRB1, and HLA-DRB5, were strongly associated with HBV-related HCC 50. Here, HLA-DRB1 is linked to hepatocellular carcinoma.