HLA-C had diagnostic value for HCC, and HLA-A, HLA-C, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB4, HLA-DRB6 and HLA-E had potentially diagnostic values for HCC. Here, HLA-DRB6 is linked to hepatocellular carcinoma.