The ANN and decision tree model of lung cancer based on the genetic polymorphism of CYP1A1, GSTM1, mEH, XRCC1, the length of telomere, and the methylations of p16 and RASSF1A gene, the results showed that the accuracy for ANN and decision tree model validation sets was 89.62% and 93.00% 53. The gene discussed is XRCC1; the disease is lung carcinoma.