Moreover, we performed receiver operating characteristic curve (ROC) analysis of HGF promoter methylation to predict NSCLC metastasis and calculated the area under the curve (AUC) of the ROC to assess the sensitivity and specificity of the prediction: the AUC values were 0.70 (P<0.05) and higher than IHC of HGF (0.62, P>0.05) (Fig. 5D). Here, HGF is linked to non-small cell lung carcinoma.