In conclusion, DHM can alleviate the symptoms of diabetic neuropathic pain and depression by regulating the level of BDNF expression in the nervous system, and its mechanism may involve the inhibition of the release of the inflammatory factors IL-1β and TNF-α.DHM is expected to become a new drug for the treatment of the comorbidity of DNP and DP. This evidence concerns the gene IL1B and major depressive disorder.