To further investigate the effect of VEGF-B overexpression on RT2 tumour progression and tumour angiogenesis, we generated double transgenic RT2-VEGF-B mice, by crossing RT2 mice with transgenic RIP-VEGF-B mice25, the latter overexpressing the human form of VEGF-B167 under the rat insulin promoter. This evidence concerns the gene VEGFA and neoplasm.