Given that patients with osteoporosis had a greater number of respiratory exacerbations, that patients receiving regular treatment with Azithromycin had significantly higher levels of undercarboxylated osteocalcin, and considering that levels of undercarboxylated osteocalcin rise with vitamin K deficiency48, it could be speculated that the higher consumption of antibiotics could predispose a sub-clinical vitamin K deficiency and a greater loss of bone mass. This evidence concerns the gene BGLAP and osteoporosis.