Although several of these immune evasive mechanisms have been evaluated in gliomas (gliomas for example have a low TMB and several studies showed that the antitumor immune response in HGGs is suppressed amongst others by enhanced PD-L1 expression17–22), most of these studies did not evaluate multiple immune parameters and/or did not evaluate potential differences between LGG and HGG. The gene discussed is CD274; the disease is central nervous system cancer.