In the present cohort (n = 61,800; mean age 62.1 years; male 67.3%), HCM patients were more likely to be obese and smokers; had a higher prevalence of comorbidities, such as hypertension, diabetes mellitus (DM), and hypercholesterolemia; more frequent use of renin-angiotensin-aldosterone system (RAS) blocker, beta blocker, calcium-channel blocker, anti-platelet agent, and statin; slightly lower systolic/diastolic blood pressures; and less frequent income lower 20% group. The gene discussed is REN; the disease is hypertensive disorder.