GYPA and leukemia: For example, Pabpc4 has been shown to bind to mRNAs associated with erythroid differentiation in mouse leukemia cells and is required for maintaining the steady-state mRNA levels of a subset of these, including CD235a/GYPA mRNA54, while Stk40 deletion leads to anemia in mouse embryos characterized by a reduction in progenitors capable of erythroid differentiation55.