The other genes have not been previously implicated in erythropoiesis, including: BRD7, a member of the bromodomain-containing protein family implicated in tumor suppression of p53 and PI3K pathways71,72; CXXC1, which encodes a key regulator of H3K4 histone methylation, cytosine methylation, cellular differentiation, and vertebrate development73; and TADA2B, which encodes a transcriptional adapter for transcriptional activation factors74. The gene discussed is CXXC1; the disease is neoplasm.