We detected m6A mRNA methylation in 70 out of 104 known/putative MDS genes, including 8 of the top 10 most frequently mutated genes (RPS19, TET2, SF3B1, ASXL1, RUNX1, DNMT3A, ZRSR2, and STAG2)75. Here, DNMT3A is linked to myelodysplastic syndrome.