Next, we investigated the regenerative capability of HLCs by injecting the cells intrasplenically into Tet-uPA (urokinase-type plasminogen activator) Rag2–/–/Il2rg–/– mice with drug-induced liver failure under uPA activation with Dox administration through injection and drinking water54 (Fig. 7a). The gene discussed is RAG2; the disease is liver failure.