As expected, YAP silencing induced the upregulation of DNA-damage-inducible transcript 4 (DDIT4), a negative YAP-target gene, and the downregulation of cysteine rich protein 61 (Cyr61), a positive YAP-target gene, both involved in opposite manner in the regulation of stemness/cancer properties in epithelial cells38,39 (Fig. 1c). This evidence concerns the gene CCN1 and cancer.