Activation of cGAS-STING as a result of chromosomal instability in certain cancer types was found to promote epithelial-to-mesenchymal transition and metastasis (Bakhoum et al., 2018), tumor growth and increased regulatory T (T reg) cell infiltration, immunoregulatory cytokine IL-10, and indoleamine 2,3-dioxygenase enzyme (Ahn et al., 2015; Liang et al., 2015; Lemos et al., 2016). The gene discussed is CGAS; the disease is neoplasm.