While we did not investigate the target cells in which SLR14 induces RIG-I activation, our data from RAG1−/− mice indicate a small but significant T cell–independent antitumor activity elicited by SLR14, presumably representing direct tumor cell death induced by SLR14 or induction of myeloid cell–dependent removal of the tumor. The gene discussed is RIGI; the disease is neoplasm.