Binding IgG antibodies directed at conserved regions of the V1/V2 loop, and antibodies mediating antibody-dependent cellular cytotoxicity (ADCC) in the presence of low plasma IgA, correlated with reduced risk of HIV infection.11, 12 The highest level of protection from HIV infection (60%) was seen during the first year of follow-up after the first vaccination in RV144, then protection waned over time in association with a drop in anti-V1/V2 titres,11, 12 indicating that regimens eliciting high and durable levels of antibodies to HIV might have enhanced efficacy. Here, CD79A is linked to HIV infectious disease.