This study further demonstrated that BEFV induces autophagy via upregulation of the PI3K/Akt/NF-κB and Src/JNK/AP1 pathways in the early to middle stages of infection and suppression of the PI3K/Akt/mTOR1 complex at the late stage of infection, thereby enhancing virus replication. The gene discussed is NFKB1; the disease is infection.