PADI2 and breast carcinoma: To identify upstream regulators of PAD2 in MCF7/TamR cells, we first performed a bioinformatics analysis using Bibiserv2 (https://bibiserv.cebitec.uni-bielefeld.de) and found that PAD2 contains a putative binding site for miR-125b-5p (Fig. 2a), which is another miR-125 family member that has been reported to be downregulated in breast cancers [26–28].