We previously reported that treatment of Mnk inhibitor CGP57380 with NSCLC cells results in different expression pattern of Mcl-1 and c-PARP, Mcl-1 expression is decreased whereas c-PARP is increased, the later plays an important role in inducing cell apoptosis through activating intrinsic mitochondrial pathway and represents cancer cell apoptotic index (AI). This evidence concerns the gene MCL1 and cancer.