MCL1 and non-small cell lung carcinoma: We previously reported that treatment of Mnk inhibitor CGP57380 with NSCLC cells results in different expression pattern of Mcl-1 and c-PARP, Mcl-1 expression is decreased whereas c-PARP is increased, the later plays an important role in inducing cell apoptosis through activating intrinsic mitochondrial pathway and represents cancer cell apoptotic index (AI).