MYC and neoplasm: Although the MYC mRNA levels were increased in BE’s progression, which was significantly higher in BE compared with normal tissues (p = 0.0227), and were much higher in EACs compared with normal tissues, (Fig. 1e) but there was no association between tumor grade, N stage, and survival and MYC expression (Additional file 1: Figure S1 and Fig. 2b, right panel).