In previous studies on the impact of flavonoid quercetin on the oral squamous cell carcinoma (OSCC), it was found that Q inhibited the cell growth in a dose-dependent way and induced apoptosis via the NF-κB pathway and inhibited the cell proliferation through G1-phase arrest and mitochondrial mediated apoptosis [30]. Here, NFKB1 is linked to oral cavity squamous cell carcinoma.