SREBF1 and cancer: SREBP1a activates genes required in the synthesis of cholesterol and fatty acid, such as elongase and stearoyl-CoA desaturase, while SREBP1c directly activates the expression of more than 30 genes dedicated to the synthesis and uptake of FAs and triglycerides.SREBP-1a is expressed at a higher level in comparison to SREBP-1c in proliferating cells, such as cancer cells, spleen, and intestinal tissues [23] and is implicated as a regulator of phospholipid biogenesis genes in mammals [24], whereas SREBP-1c is the predominant form of the SREBF1 gene product in vivo, particularly in hepatocytes.