Statistical analyses of these 219 cases revealed that patient age (p = 0.048), sample type: metastatic sample versus primary colon carcinoma (p = 0.014), gene mutations in K-Ras (p = 0.019) and B-Raf (p = 0.002), and the staging parameter M (p = 0.047) were positively correlated with PDX success. Here, KRAS is linked to colon carcinoma.