Neither did tumor localization (right, transverse, left, sigma, or rectum), molecular subtype (microsatellite status, CpG island methylation, or chromosomal instability), MSI status, staging parameters: T, M, R, L, and V, UICC classification nor genetic mutations in TP53, APC, K-Ras, B-Raf, and PIK3CA seem to be relevant. The gene discussed is BRAF; the disease is neoplasm.