DNA damage analysis of CLL cells treated with 10 μM IDE for 18 h, either alone or combined with CD40L/IL4, showed no IDE-dependent change in the number of DNA breaks Compared to cells incubated in media alone, cells incubated with CD40L/IL4 appeared to have less breaks, regardless of the presence of IDE. This evidence concerns the gene IL4 and B-cell chronic lymphocytic leukemia.