For example, a study performed by Xue et al. found that hypoxia could decrease GR expression in hearts from fetal, 3-week-old, and 3-month-old rats, resulting in decreased GR binding to GREs at the AT2R promoter, which was then followed by improved post-ischemia recovery of left ventricular function and avoidance of the fetal hypoxia-induced cardiac ischemic vulnerability [132]. The gene discussed is NR3C1; the disease is ischemia.